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Filtered Search Results
Medchemexpress LLC Filgotinib (maleate) | 1802998-75-9 | 99.88% | 541.58 | 100 MG
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Filgotinib maleate is a selective, orally available JAK1 inhibitor with anti-inflammatory and antiviral activities. It inhibits the activities of JAK1, JAK2, JAK3, and TYK2. It also inhibits HIV-1 driven gene transcription and reduces the proliferation of HIV-1 infected cells. It is used in the study of rheumatoid arthritis and inflammatory bowel disease.
- Selectively inhibits JAK1 with high potency
- Demonstrates anti-inflammatory and antiviral properties
- Inhibits Th2 and Th1 cell differentiation in a dose-dependent manner
- Produces dose-dependent bone damage protection in rat models of collagen-induced arthritis
- Reduces inflammatory cell infiltration and protects articular cartilage and bone
- Reduces serum levels of inflammatory cytokines and chemokines
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Medchemexpress LLC Ro 25-6981 Maleate | 1312991-76-6 | 99.25% | 455.54 | 100 MG
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Ro 25-6981 Maleate is a potent, selective, and activity-dependent NR2B subunit-specific NMDA receptor antagonist. It demonstrates anticonvulsant and anti-parkinsonian activity and has potential for research into Parkinson's disease.
- Potent, selective, and activity-dependent NR2B subunit-specific NMDA receptor antagonist
- Demonstrates anticonvulsant activity
- Demonstrates anti-parkinsonian activity
- Potential for Parkinson's disease research
- Induces contraversive rotations in 6-OHDA-lesioned rats
- Exhibits age- and activation-dependent anticonvulsant action
- Shows analgesic effects on incision pain in rats
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Medchemexpress LLC Trimebutine (maleate) | 34140-59-5 | 99.66% | 5 G
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Trimebutine (maleate) | 34140-59-5 | 99.66% | 5 G
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Medchemexpress LLC Indacaterol maleate | 753498-25-8 | 99.6% | C28H32N2O7 | 50 MG
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Indacaterol maleate (Standard) is the analytical standard of Indacaterol maleate and is intended for research and analytical applications. It is an orally active ultra-long-acting β2 adrenergic receptor (ADRB2) agonist that inhibits NF-κB activity in a β-arrestin2-dependent manner. This helps in preventing further lung damage and improving lung function in COPD.
- Can be used in cardiovascular disease research.
- Commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Helps in preventing further lung damage and improving lung function in COPD.
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Medchemexpress LLC Zetomipzomib maleate 1mg | 2170983-62-5 | 1 MG
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Zetomipzomib maleate is a selective immunoproteasome inhibitor (KZR-616 maleate) used as a research reagent to study autoimmune and inflammatory pathways. It is supplied as a small, research-scale sample suitable for in vitro and preclinical work.
- Selective inhibitor of immunoproteasome subunits LMP7 and LMP2.
- Suitable for preclinical research and mechanistic studies.
- Provided as a low-amount research sample for laboratory use.
- Stored and handled according to reagent safety protocols and SDS guidance.
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Medchemexpress LLC Orvepitant maleate | 579475-24-4 | 100.0% | 10MM 1ML
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Orvepitant maleate | 579475-24-4 | 100.0% | 10MM 1ML
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Medchemexpress LLC Avitinib maleate | 1557268-88-8 | 99.86% | 603.60 | 1 ML
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Avitinib maleate (Abivertinib) is a third-generation, irreversible, and orally active selective EGFR inhibitor. It has IC50 values of 0.18 nM against EGFR L858R and EGFR T790M, and 7.68 nM against wild-type EGFR. Additionally, Avitinib maleate acts as a BTK inhibitor, inducing apoptosis and inhibiting BTK phosphorylation in mantle cell lymphoma. This compound demonstrates anticancer effects and is intended for research use only.
- Third-generation, irreversible, and orally active selective EGFR inhibitor.
- Potent inhibition of mutant EGFR phosphorylation with high selectivity over wild-type EGFR.
- Inhibits phosphorylation of downstream targets such as Akt and ERK1/2 in specific cell lines.
- Also functions as a BTK inhibitor, inducing apoptosis and inhibiting BTK phosphorylation in mantle cell lymphoma.
- Demonstrates anticancer effects in xenograft models, inhibiting EGFR-mutant tumor growth.
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Medchemexpress LLC Perhexiline (maleate) | 6724-53-4 | 100 MG
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Perhexiline maleate is an orally active CPT1 and CPT2 inhibitor that reduces fatty acid metabolism. It induces mitochondrial dysfunction and apoptosis in hepatic cells. It can cross the blood brain barrier (BBB) and shows anti-tumor activity. It can be used in the research of cancers, and cardiovascular diseases like angina.
- Reduces fatty acid metabolism
- Induces mitochondrial dysfunction and apoptosis in hepatic cells
- Can cross the blood-brain barrier
- Exhibits anti-tumor activity
- Suitable for research in cancers and cardiovascular diseases like angina
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Apexbio Technology LLC NB-598 Maleate 155294-62-5 10mM (in 1mL DMSO)
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NB-598 Maleate is a small-molecule inhibitor targeting squalene epoxidase (SE) an essential enzyme in cholesterol biosynthesis It is designed to inhibit SE thereby disrupting the oxygenation of squalene and affecting downstream synthesis of cholesterol intermediates particularly within farnesol-dependent pathways leading to triglyceride biosynthesis NB-598 Maleate exerts its biological activity primarily through inhibition of squalene epoxidase In mouse pancreatic islet models NB-598 Maleate reduces insulin secretion under both basal and glucose-stimulated conditions Additionally this compound inhibits calcium voltage-dependent (CaV) ion channels in cellular assays Based on these pharmacological properties NB-598 Maleate holds research potential in studying cholesterol biosynthesis pathways lipid metabolism insulin regulation and the physiological role of CaV channels
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Apexbio Technology LLC NB-598 Maleate 155294-62-5 200mg
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NB-598 Maleate is a small-molecule inhibitor targeting squalene epoxidase (SE) an essential enzyme in cholesterol biosynthesis It is designed to inhibit SE thereby disrupting the oxygenation of squalene and affecting downstream synthesis of cholesterol intermediates particularly within farnesol-dependent pathways leading to triglyceride biosynthesis NB-598 Maleate exerts its biological activity primarily through inhibition of squalene epoxidase In mouse pancreatic islet models NB-598 Maleate reduces insulin secretion under both basal and glucose-stimulated conditions Additionally this compound inhibits calcium voltage-dependent (CaV) ion channels in cellular assays Based on these pharmacological properties NB-598 Maleate holds research potential in studying cholesterol biosynthesis pathways lipid metabolism insulin regulation and the physiological role of CaV channels
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Electron Microscopy Sciences DMA N, N-Dimethylaminoethyl Methacrylate 450 ML
CAS #2867-47-2 C₈H₁₅NO₂ F.W. 157.21
Boiling point: 76°C
A water soluble monomer.
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eMolecules Methyl 4-fluorocinnamate | 96426-60-7 | MFCD00297011 | 25g
Oakwood Chemical | Methyl 4-fluorocinnamate | 25g | 537706891 | 098862 | | 96426-60-7 | MFCD00297011 | 180.178 | C10H9FO2
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Cayman Chemical Thioperamide maleate
A selective histamine H3 receptor antagonist that crosses the blood-brain barrier; binds to rat cerebral cortical cells in vitro with a pKi value of 8.4
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eMolecules Glyceryl ascorbate | 1120360-13-5 | MFCD28386108 | 1g
Chem-Impex | Glyceryl ascorbate | 1g | 490842859 | 32378 | | 1120360-13-5 | MFCD28386108 | 250.203 | C9H14O8
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Apexbio Technology LLC Flupirtine maleate 75507-68-5 1g
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Flupirtine maleate (CAS 75507-68-5) is a non-opioid analgesic compound characterized by its modulatory effects on neuronal excitability It acts primarily by opening neuronal potassium channels leading to membrane stabilization and reduced excitatory neurotransmission Additionally flupirtine exerts indirect antagonism of N-methyl-D-aspartate (NMDA) receptors which contributes to its analgesic and muscle relaxant effects Due to this dual mechanism flupirtine maleate is utilized in research focusing on pain modulation neuroprotection and the investigation of NMDA receptor-mediated pathways
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